When autism spectrum disorder co-occurs with intellectual disability, the cause may be a converging mechanism of two higher-ranking risk genes.
Summary: Mutations in the ASD/intellectual disability genes ADNP and POGZ lead to abnormal activation and overexpression of immune response genes and microglia genes. This results in abnormal synaptic function in the brain, which is a feature of ASD and ID. source: University of Buffalo Scientists at the University of Buffalo have discovered a converging mechanism … Read more